The True Risks of Low Vitamin D Levels

Vitamin D, the “sunshine vitamin,” is important for your body to function. One of the major benefits of vitamin D is the building of strong bones. Supplementation with vitamin D has largely eliminated rickets as a childhood disease. More recently, low vitamin D levels have been associated with a number of illnesses. Likewise, attaining appropriate levels of the vitamin has been associated with improvement in a number of conditions.

Functions of Vitamin D

Some of the functions of Vitamin D in the body include:

  • Helping the body absorb calcium more effectively
  • Helping to keep proper calcium and phosphate levels
  • Stimulating the growth of bones and cells
  • Reducing inflammation
  • Regulating mental health, including Seasonal Affective Disorder
  • Aiding in serotonin and dopamine synthesis
  • Helping increase levels of glutathione in your body

Symptoms of Low Vitamin D Levels

The percent of people with low vitamin D levels in the country is estimated to be from 30% to 95%. These estimates depend on the age of the individual and where they live. Three out of four pregnant women have low vitamin D levels. Vitamin D is an important nutrient, and not having enough could cause later health issues for these growing babies.

Having low vitamin D levels don’t always cause symptoms. Some people won’t begin showing symptoms until their levels are very low or have been low for some time.

Low vitamin D levels can result in the following issues:

Low vitamin D levels and the symptoms associated with them

  • Bone pain and weak muscles
  • Possible increased risk of death from cardiovascular disease
  • Cognitive impairment in the elderly
  • Cancer or faster growth of some cancers
  • Increased incidence of severe asthma in children
  • Unexplained fatigue
  • Increased risk of bone fractures
  • Deformities brought on by soft bones
  • Lower levels of essential neurotransmitters
  • Increased risk of infection due to impaired immune function
  • Blood sugar problems due to increased insulin resistance
  • Increased risk for osteoporosis
  • Joint pain
  • Increased weight gain
  • High blood pressure
  • Restless sleep
  • Headaches
  • Metabolic syndrome and diabetes
  • Autoimmune diseases

Reasons for Low Vitamin D Levels

Researchers have found that many people have startlingly low vitamin D levels, not only in this country, but around the world. There are a number of reasons for this.

Not enough vitamin D in your diet. The number of people who aren’t getting enough vitamin D from the foods they eat is increasing: https://www.drlam.com/articles/adrenal_fatigue.asp Natural sources of vitamin D include foods like egg yolks, fish, fish oil, and beef liver. Vitamin D can also be found in fortified foods like milk and yogurt. However, most foods contain only small amounts of vitamin D, so it is nearly impossible to get enough from food sources alone.

You don’t get enough sun. Your body makes vitamin D when your skin is exposed to sunlight. If you wear sunscreen, you’re hampering the body’s ability to do this. If you wear long sleeves or clothing that covers your body too much, your skin can’t make enough vitamin D. If you live in the far northern or southern hemisphere, especially during the winter, there may not be enough UV light even with full sun exposure for your body to make vitamin D.

You have darker skin. Darker skin coloring reduces the amount of vitamin D the skin makes with exposure to the sun. This may also be an issue for older people with more melanin in their skin.

Your kidneys aren’t doing their conversion job. Especially as you age, your kidneys can become less efficient in converting vitamin D to its active form. This can lead to low levels of vitamin D.

Your body doesn’t absorb vitamin D well. Various intestinal conditions can cause vitamin D to be poorly absorbed. Crohn’s disease, cystic fibrosis, and celiac disease are some of the more prevalent conditions that keep you from absorbing vitamin D.

Obesity. Fat cells remove vitamin D from the blood, making it less available for the body. If the body mass index is over 30, this may lead to low levels of vitamin D.

Vitamin D and Autism

Low vitamin D levels and autism

Recent research has shown a connection between low vitamin D levels and autism. One possible mechanism is a link between glutathione levels, mercury and other heavy metals, oxidative stress, and autism. This works because low levels of vitamin D also means low levels of glutathione.

Research has shown a primary reason heavy metals lead to toxicity in the brain is lower levels of glutathione. This chemical is a binding agent that adheres to heavy metals and helps remove them from the body. People with autism have particular difficulty excreting heavy metals. Thus, with lower levels of vitamin D leading to lower levels of glutathione, people with autism are at greater risk of having high levels of heavy metals in their bodies.

While children without autism are able to excrete mercury from their bodies, those with autism may not be able to do so. Mercury in vaccines used in children may have caused injury to those children with autism through this mechanism.

This research gains in importance when the risk factors for autism are considered. Risk factors include:

  • Toxins in the environment, such as heavy metals and chemicals
  • Genetic factors
  • Older parents
  • Mothers taking certain medications that interfere with the metabolism of vitamin D
  • Complications in pregnancy and delivery

Some of these risks are associated with vitamin D deficiency. One factor that is present in autism is oxidative stress. Research has shown vitamin D to fight oxidative stress. Lower levels of vitamin D would lead to more oxidative stress.

The environmental risks from toxins often lead to DNA damage and increased risk of autism. Vitamin D both protects against and repairs DNA damage. It also increases glutathione which helps remove toxins from the body.

The anti-inflammatory properties of vitamin D can also help protect against worsening autism symptoms. It has anti-autoimmunity properties, can increase the seizure threshold, increases T-regulatory cells that calm the immune system, and protects mitochondria.

The connection between vitamin D and autism seems clear. More research is needed to further delineate this connection and point to possible ways to either prevent or remedy autism though.

Vitamin D and Neuromuscular Disorders

Vitamin D appears to be a major player in the development of some neuromuscular disorders. Researchers have found this connection in a number of different studies recently.

One of these studies, reported to the American Association of Neuromuscular and Electrodiagnostic Medicine convention, indicated a majority of people with neuromuscular conditions also suffer from a low level of vitamin D.

Another study, reported in the journal Neurology in 2014, showed older adults with deficiencies in vitamin D had more than double the risk of developing dementia. One of the most frequently seen forms of dementia is Alzheimer’s disease. Up to 80% of dementia cases are Alzheimer’s.

The subjects for this study were about 1600 adults, age 65 or older, who did not have dementia. Low levels of vitamin D increased dementia risk by 53%. Those subjects with severe deficits in vitamin D had a 125% increased risk of developing dementia compared to people with normal vitamin D levels. Those with low levels of vitamin D had a 70% increased risk of developing Alzheimer’s, and the risk jumped to 120% if they had severe deficits in vitamin D. How vitamin D levels are linked with these conditions isn’t clear. It’s possible that this vitamin somehow helps clear the plaques in the brain associated with dementia.

Another study reported in the journal JAMA Neurology showed people who already have multiple sclerosis (MS) suffer from an increase in the severity and progression of the condition with low vitamin D. Early stage MS sufferers with normal levels of vitamin D developed 57% fewer new brain lesions and had an equally reduced risk of relapse than those with low vitamin D levels. Researchers also suggested that having adequate levels of vitamin D would likely increase the effectiveness of some MS remediation efforts, especially when utilizing interferon beta 1b.

The protective role this nutrient plays in the brain and central nervous system has been suggested from animal studies. If this is the case, it seems logical to think low vitamin D levels in people would make it more likely for them to develop neurodegenerative disorders as they get older.

Parkinson's disease and Low vitamin D levels

A recent study involving people with Parkinson’s disease showed about 70% of those with the condition also had low levels of vitamin D. Earlier research by these same researchers showed 55% of the people they studied with Parkinson’s had low vitamin D levels. 41% of Alzheimer’s patients in the study also had low levels of vitamin D. Only 36% of healthy older adults had low levels of this vitamin.

The new research investigating untreated Parkinson’s sufferers found about 95% of them had low levels of vitamin D. These people were followed for 20 months. The researchers found vitamin D levels did not decrease during that time, though the symptoms of Parkinson’s increased. This suggested two things. One, simply increasing levels of vitamin D did not stop or improve symptoms of Parkinson’s. Two, people who develop Parkinson’s may have had low levels of vitamin D for years.

Vitamin D and Other Disorders

Research indicates there is a definite connection between vitamin D levels and numerous significant medical conditions. This connection is important both for preventing and remediating these conditions.

Seasonal Affective Disorder

One study reported in the 2014 issue of Medical Hypotheses found a link between vitamin D deficiency and Seasonal Affective Disorder (SAD), a form of depression. Lack of this vitamin appeared to be a contributing factor in the development of this depression.

The lack of seasonally available sunlight seemed to be the primary factor in the development of SAD. This may be because vitamin D is involved in the synthesis of serotonin and dopamine, neurotransmitters involved in the development of depression. Low levels of these chemicals are associated with depression. When there is less vitamin D being produced by sunlight, lower levels of these chemicals can lead to SAD. Thus, there is a connection between low levels of vitamin D and depression.

The growth of Cancer Cells

Research has shown breast cancer cells grow faster in an environment with low levels of vitamin D. This research from the Stanford University of Medicine indicates a significant and direct link between the amount of vitamin D circulating in the body and the expression of ID1, a gene that is known to be involved in tumor growth and metastasis of breast cancer.

It was hypothesized before that higher levels of vitamin D inhibit the expression of ID1. This research showed a metabolite of the vitamin directly controls the expression of ID1 in breast cancer cells.

Prostate Cancer

The journal Clinical Cancer Research published a study in 2014 showing a link between low levels of vitamin D and prostate cancer. Prostate cancer is the most frequently occurring cancer in men and the second most common cause of death for American men. This study showed that low levels of vitamin D led to an aggressive growth of prostate cancer in European-American and African-American men.

In the study, 667 men between ages 40 to 79 underwent prostate biopsies. African-American men with low levels of vitamin D had an especially increased risk of testing positive for prostate cancer.

Heart Disease

Low vitamin D levels and heart disease

Low levels of vitamin D have been associated with increased risk of heart disease. Research shows 70% or more of those who underwent a coronary angiogram had a low level of vitamin D. The American College of Cardiology says vitamin D deficiency has been linked to more severe cases of heart disease.

Psoriatic Arthritis

A study in the journal Arthritis Care and Research reported that 62% of people with psoriatic arthritis had low levels of vitamin D. Other research has shown low levels of vitamin D may increase inflammation, making this form of arthritis worse. The mechanism involved may be increased white blood cell levels.

Pneumonia

Another study from the University of Eastern Finland found low levels of vitamin D led to 2.5 times greater risk of developing pneumonia. Other research suggests the mechanism behind this dramatic increase may be the suppression of the immune system that comes with low levels of vitamin D.

Erectile Dysfunction

The Journal of Sexual Medicine reported a study in 2014 that found men with severe erectile dysfunction (ED) had much lower levels of vitamin D than men with mild ED. This is the most frequent sexual problem among men and may stem from other conditions as well.

Schizophrenia

The risk of developing this serious mental condition may be increased by low vitamin D levels. People with this deficiency are twice as likely to develop this condition as those without a deficiency. This is according to a study published in the 2014 edition of the Journal of Clinical Endocrinology and Metabolism. Schizophrenia is a severe disorder of the brain affecting more than two million American adults. There is no permanent fix, but there are things you can do about the condition.

Increasing Vitamin D Levels

There is some confusion about the optimum levels of vitamin D. Part of this confusion has to do with our bodies being able to produce vitamin D from the sun. This way of obtaining vitamin D makes it difficult to determine exactly how much is needed from foods and supplements.

 

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